- Bioluminescence is an energy-conserving process of natural production of cold light that many lower organisms use for communication, capturing prey, or mating.
- This wondrous phenomenon has long fascinated scientists and the public, but many details of the chemical reactions used to produce light remain unclear. For example, it remains uncertain why various beetle species can emit different colors of light, despite using very similar light-producing enzymes.
- Understanding the chemical reactions responsible for bioluminescence could lead to the development of new bioanalytical tools, such as those for early discovery of cancer and diagnostics of other diseases.
Abu Dhabi, UAE, December 10, 2020: A team of researchers from the NYU Abu Dhabi’s (NYUAD) Smart Materials Lab (SML) led by Professor of Chemistry Panče Naumov has conducted a thorough review of the scientific literature surrounding the natural production of light, called bioluminescence, and developed conclusions that will help others in the field direct their research to uncover the mysteries behind this fascinating natural phenomenon.
In the new study The Elusive Relationship Between Structure and Color Emission in Beetle Luciferases, which is featured on the cover of the journal Nature Reviews Chemistry, Naumov and colleagues provide the most comprehensive critical overview of the field of the bioluminescence of beetles, including fireflies, to date.
The NYUAD researchers, including the Naumov group’s post-doctoral associates César Carrasco-López and Stefan Schramm, and undergraduate student Nathan M. Lui, identify the intricate structural factors that govern what color light is emitted by wild-type and mutant luciferases, the enzymes that generate light. They also demonstrate that it is possible to build a library of bioluminescent enzymes in the future, which will enable researchers to control the color and intensity of light emission by engineering luciferases at will.
“Learning from nature will provide us with tools to engineer luciferases that can emit colors within a large range of energies,” said Naumov. “This will eventually help us expand the range of application of these and similar enzymes for some exciting applications in biology and medicine, including early diagnosis and prevention of diseases.”
Throughout human’s history, bioluminescence has been an inspiration to scientists, artists, and laypersons. Glowing fungi or ostracods have been used by tribes and soldiers as lanterns to guide their way through jungles without the need of electricity, and fireflies were used by miners as safety lights.
The Nobel Prize in Chemistry in 2008 was awarded for the discovery of the green fluorescent protein, a bioluminescent protein found in the jellyfish Aequorea victoria. Today, bioluminescence is the basis for a great number of bioanalytical methods, such as cell imaging, cancer research, and control of food contamination, and a way to efficiently convert the energy stored in chemical bonds into light that can be easily detected. For example, bioluminescence of some bioluminescent bacterial strains is used to monitor water toxicity and contamination. The fluorescent proteins are genetically inserted into cells and animals to analyze important aspects of dynamics of some diseases.
The latest research from the NYUAD’s Naumov team is poised to solve some of the mysteries surrounding the chemistry of bioluminescence and to bring this research closer to applications.
Reference: Carrasco-López, C., Lui, N.M., Schramm, S. et al. The elusive relationship between structure and colour emission in beetle luciferases. Nat Rev Chem (2020). https://doi.org/10.1038/s41570-020-00238-1
Provided by New York University
About NYU Abu Dhabi
NYU Abu Dhabi is the first comprehensive liberal arts and science campus in the Middle East to be operated abroad by a major American research university. NYU Abu Dhabi has integrated a highly-selective liberal arts, engineering and science curriculum with a world center for advanced research and scholarship enabling its students to succeed in an increasingly interdependent world and advance cooperation and progress on humanity’s shared challenges. NYU Abu Dhabi’s high-achieving students have come from more than 115 nations and speak over 115 languages. Together, NYU’s campuses in New York, Abu Dhabi, and Shanghai form the backbone of a unique global university, giving faculty and students opportunities to experience varied learning environments and immersion in other cultures at one or more of the numerous study-abroad sites NYU maintains on six continents.