Researchers found that fish oil does not reduce the risk of developing atrial fibrillation (AF) , the most common disturbance of heart rhythm. Similarly, vitamin D supplements have no protective effect against arrhythmias. The findings were published in JAMA.
In this ancillary primary prevention AF trial that was embedded within a 2 × 2 factorial randomized clinical trial and included 25 119 participants without AF at study entry, there was no significant difference in AF incidence with marine omega-3 fatty acids vs placebo (hazard ratio, 1.09) or with vitamin D3 supplementation vs placebo (hazard ratio, 1.09) over a median 5.3 years of treatment and follow-up.
These findings do not support the use of marine omega-3 fatty acids or vitamin D3 in adults to prevent AF.
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Albert CM, Cook NR, Pester J, et al. Effect of marine omega-3 fatty acid and vitamin D supplementation on incident atrial fibrillation: A randomized clinical trial. JAMA. 2021;325(11):1061-1073. doi:10.1001/jama.2021.1489
Provided by Physicians Committee for Responsible Medicine