Which Medications Are Most Toxic to the Liver? (Medicine)

A new study published in the British Journal of Clinical Pharmacology ¬provides insights on how common hospitalized patients develop liver injury from taking different medications.

When investigators analyzed the records of 156,570 hospitalized patients, they found 499 cases of drug-induced liver injury (DILI), for an incidence of 0.32%. Anti-infective agents, cancer medications, and nonsteroidal anti-inflammatory drugs were the major categories of drugs causing DILI, and the highest incidence was due to voriconazole (an antifungal medication). Patients with high cholesterol, cardiovascular disease, pre-existing liver disease, and prior surgeries faced a higher risk of DILI.

“We have carried out DILI-related real-world study with the help of information technology to provide a more accurate reference for safe and rational drug use,” said corresponding author DaiHong Guo, of the Chinese People’s Liberation Army General Hospital, in Beijing.


Reference: Kong, X, Guo, D, Liu, S, Zhu, Y, Yu, C. Incidence, characteristics and risk factors for drug‐induced liver injury in hospitalized patients: A matched case‐control study. Brit Jnl Clinical Pharma. 2021; 1– 9. https://doi.org/10.1111/bcp.14847


Provided by Wiley

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